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apalutamide will minimize the extent or result of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medications which might be CYP3A4 substrates can lead to lessen publicity to these prescription drugs.Compared, common failur